Overcoming roadblocks in computational roadmaps to the future for safe nanotechnology

Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering.

Transplantations of various stem cells or their progeny have repeatedly improved cardiac performance in animal models of myocardial injury; however, the benefits observed in clinical trials have been generally less consistent. Some of the recognized challenges are poor engraftment of implanted cells and, in the case of human cardiomyocytes, functional immaturity and lack of electrical integrati...

Roadmaps at 2015 on Nanotechnology Application in the Sectors Of:

Roadmaps at 2015 on Nanotechnology Application in the Sectors

All roadmaps reports are under revision of the European Commission, final approval from the EC is pending. The present document is a roadmap report prepared by Willems & van den Wildenberg (W&W) in the framework of the NanoRoadMap (NRM) project, co-funded by the 6th Framework Programme (FP6) of the European Commission. This roadmap report is mainly based on the input received from experts parti...

Overcoming the translational roadblocks: a cancer care and research model

There are many challenges to the process of translating the knowledge gained in the laboratory into new clinical approaches that can meet the needs of patients, clinicians and the wider community. We describe here an initiative that has borrowed concepts and principles from participatory research to produce a new process embedded in a cancer center aiming to facilitate translational research an...

Pluronic Nanotechnology for Overcoming Drug Resistance

Chemotherapy is one of the most conventionally used therapeutic interventions for treating various diseases. Chances of acquiring multidrug resistance in response to chemotherapeutic agents are exceedingly common among patients. Drug resistance arises mainly due to overexpression of efflux transporters such as P-glycoprotein and multidrug resistance-associated protein of the ATP-binding cassett...